Philosophy of Genetics

What you want is who you can become. You're free to do what you want, but you can't choose your wants themselves (desires and motivations), which are innate and vary from person to person.

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  • Will Frehley: Leadership is Innate
  • Will Frehley: Napoleon in Shanghai

    Will Frehley: Napoleon in Shanghai

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  • Center for Genetics and Society
  • Database of Genomic Variants
  • Genetics and Public Policy
  • Science Daily
  • Human Gene Mutation Database
  • Genetic Alliance
  • International HapMap Project
  • Genetics 101
  • Gene Search
  • Personality-related Gene Variants
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Employers not compliant with new GINA law

According to the New York Times:

The most important new antidiscrimination law in two decades — the Genetic Information Nondiscrimination Act — will take effect in the nation’s workplaces [on Nov 21, 2009], prohibiting employers from requesting genetic testing or considering someone’s genetic background in hiring, firing or promotions.

Furthermore:

“There’s an absolute ban on the use of genetic information to make any kind of decision about employment,” said Christopher Kuczynski, assistant legal counsel with the commission.

Talent It's easy to see how the new law "prohibits employers and health insurers from asking employees to give their family medical histories", for example "not promoting a 49-year-old to chief executive because it knew his father and grandfather died of heart attacks at age 50".

But what about more subtle forms of discrimination, where personality traits are used as genetic surrogates?  One of the most celebrated CEOs of the last 25 years, Jack Welch, openly sought and hired leaders who "exude energy”, are “able to inspire confidence”, and are “optimistic” and “comfortable in their own skin”.  He admitted that IQ, energy level, and charisma are probably innate.

Welch's approach is widely copied in corporations today.  Indeed, Performance vs Potential assessments make use of genetically-linked proxy traits to differentiate and promote high-potential employees.  Doesn't GINA make these tests illegal as well?

November 20, 2009 in DNA and Society | Permalink | Comments (0)

Sandel's Genetics and Morality

Harvard University professor Michael Sandel has recently tried to make the case for limiting individual reproductive choice. His none-too-subtle agenda is to maintain the advantages of the genetic elites, such as himself, at the expense of the rest of society.

Sandel Sandel says he's against allowing parents to choose their children's genes. He assumes (correctly) that many social advantages (energy level, self-confidence, intelligence) are innate, and unevenly distributed.  Secretly, he's happy that he can pass along his own traits (ability to focus for long periods, mild charisma) to his children.  (I say "his children" to refer to the children of meritocrats generally.)  But he dreads that the great unwashed masses will soon be able to alter their own genes to be more like his, since then his children would become less rare and special in their innate traits.

Sandel says "there remains something troubling with the ambition to control the genetic characteristics of the next generation".  That's all very well for someone who's already born with the "gifted character of human powers" (i.e. the genes for success).  But what if you're born with other genes?  You'll never achieve as much social influence or status as Sandel and his kids.

Sandel worries that the "meritocracy, less chastened by chance, would become harder, less forgiving".  Yeah, and meritocrats would also become more commonplace, leading to less social disparity in income and status.  Today, corporations pay millions in salary and bonues to a rare cadre of super-smart, super-motivated genetic elites, who can in turn afford better lifestyles, better healthcare, and greater social influence (through political donations, ability to launch a national journal, etc).

"Changing our nature to fit the world," argues Sandel, "is actually the deepest form of disempowerment."  Really?  For you, perhaps.

September 12, 2009 in DNA and Society | Permalink | Comments (0)

European Invasion

According to the New York Times:

Europe has been colonized three times in the distant past, always from the south. Some 45,000 years ago the first modern humans entered Europe from the south. The glaciers returned around 20,000 years ago and the second colonization occurred about 17,000 years ago by people returning from southern refuges. The third invasion was that of farmers bringing the new agricultural technology from the Near East around 10,000 years ago.

The pattern of genetic differences among present day Europeans probably reflects the impact of these three ancient migrations, Dr. Kayser said.

July 29, 2009 in DNA and Society | Permalink | Comments (0)

Gregory Stock's DNA

Here are some excerpts from "Redesigning Humans" written in 2002 by Gregory Stock, former director of UCLA’s Program on Medicine, Technology and Society:

Stock_photo Future parents … will be able to select their children’s [genetic] modules from an expanding common library of enhancements. (p. 192)

People’s genetics would become a manifestation of their parents’ values and predilections. (p. 191)

[There will be] a genetic bazaar where all parents can obtain equivalent talents and potentials for their children. (p. 190)

Rare, special attributes such as photographic memory or extraordinary athletic ability may become both more extreme and more commonplace. (p. 193)

Once we can fashion our children’s biological predispositions, many cultural and personal influences will feed directly into biology. (p. 194)

Future sources of parental dissatisfaction are easy to predict. Some parents will forego germinal choice technology and end up wishing they had used it. (p. 148)

If such interventions become commonplace, the result will be revolutionary, because it will be a major step toward equalizing life’s possibilities. (p. 190)

Provision of free universal access to … [germinal choice technology (GCT)] would align better with our ideals of equal opportunity for children and might be surprisingly affordable. (p. 186)

Dna_tattoo The gifted of today ultimately may not welcome such a leveling, because it would diminish the edge their children enjoy and make society very competitive, even for the best endowed. (p. 190)

Strong voices will oppose [germinal choice technology (GCT)], but most of the warnings … will come from people with the most to lose – the well-endowed elite. (p. 190)

Critics like Leon Kass … aren’t worried that this technology will fail, but that it will succeed, and succeed gloriously ... [and] tear the fabric of our society. (p. 12)

Policymakers sometimes mistakenly think that they have a choice about whether germinal technologies will come into being. They do not. (p. 172)

Prohibitions are easy political gestures. But once GCT arrives, enforcement will be nearly impossible. (p. 166)

Government abuse is what we must fear, not germinal choice technology (GCT). (p. 199)

Direct human germline manipulations may still be a decade or two away, but methods of choosing specific genes in an embryo are in use today to prevent disease. (p. 2)

Artificial chromosomes … might allow cheap enhancement for the many. (p. 186)

The arrival of safe, reliable germline technology will signal the beginning of human self-design. (p. 3)

May 13, 2009 in DNA and Society | Permalink | Comments (1)

Open Letter to Health Secretary, and its flaws

Kathleen Sebelius, the Secretary of Health and Human Services, was recently sent a (flawed) open letter requesting greater oversight of genetic tests:

At the core of personalized medicine is advanced [genetic] diagnostic testing that improves a physician's ability to assess whether an individual patient is or is not likely to benefit from treatments for his or her disease or condition. Advanced diagnostic testing is becoming the standard of care for many diseases.

Accurate, reliable, and timely advanced diagnostics offer enormous promise, but poor quality testing can harm patients and waste scarce resources. Therefore, it is critical that regulatory oversight of these innovations (and innovators) strike the right balance between assuring patient safety and embracing policies that encourage the incorporation of rapidly advancing scientific methods and knowledge.

Sounds reasonable. We all want "accurate, reliable, and timely advanced diagnostics" for disease.  So what's the problem?

The problem is that the letter makes several wrong assumptions about what these genetic tests are all about.  Here are my issues:

  1. Notice the use of the term "patient".  We shouldn't be medicalizing genes.  We're not patients, we're people with unique gene variants. Genes are not something you have. They are something you are. They define you, like a fingerprint.  They form the human character.
  2. Most genetic variations are not involved in disease.  Instead, they are responsible for human diversity.  There's no such thing as a "disease gene".  Most genes come in different variants or flavors, and a few variants or normal genes can contribute to disease.  But all genes have a normal function first.
  3. Genetic tests are not expensive, and they're getting even cheaper. Instead of running one lab test at a time, why not sequence your entire genome once and have it on file. Testing your most common genetic variants runs around $399 today, and a full genome scan currently runs $100,000, although this should decrease to around $1,000 in a few years.
  4. Genetic tests are not dangerous.  You simply take some saliva or blood, and that's it.  The test can't hurt you. A genetic test simply reveals an objective fact about you, specifically your unique gene variants or flavors.  We're all 1% different, genetically-speaking.

Doctor It's the claim about the gene function that the letter writers are trying to control, under the guise of regulating genetic tests.  The government is being urged to regulate all claims on gene function.  Yet we have over 20,000 genes.  Is the government going to control information on all of these?  Again, most genetic diversity is not disease-related.

Why not allow anyone to make claims on what our genes do, in a great marketplace of ideas?  We're smart enough to consider the source, and make our own decisions.  We don't need the government intervening to block the free flow of information about ourselves.

There's also the question of fairness.  Some genetic variants give you greater energy-level, intelligence, charisma, and resilience, often leading to higher pay and social status.  Since most doctors already have these innate qualities, they're simply trying to keep their talents rare (and salary high), by having the government block access to genetic information by the rest of us.

May 05, 2009 in DNA and Society | Permalink | Comments (0)

Designer Babies

There's a media frenzy (see the Today Show and ABC News) and pent-up demand for designer babies, and fertility clinics now have the tools to design them. 

A recent survey conducted by the New York University School of Medicine found that:

A majority [of people seeking genetic counseling] said they supported prenatal genetic tests for the elimination of certain serious diseases ... 56% supported using them to counter blindness and 75% for mental retardation. More provocatively, about 10% of respondents said they would want genetic testing for athletic ability, while another 10% voted for improved height. Nearly 13% backed the approach to select for superior intelligence. (Wall Street Journal)

Now, researchers have found a way to perform pre-implantation genetic diagnosis (PGD) on fertilized eggs, before they are implanted in the mother:

William Kearns, a medical geneticist and director of the Shady Grove Center for Preimplantation Genetics in Rockville, Md., ... described how he had managed to amplify the DNA available from a single embryonic cell to identify complex diseases and also certain physical traits.

According to Dr. Steinberg, the head of Fertility Institutes, "We intend to offer [trait selection services] soon."

February 18, 2009 in DNA and Society | Permalink | Comments (0)

James Watson's DNA

James_watson Here are excerpts from "DNA: The Secret of Life" written in 2003 by James Watson, the co-discoverer of the DNA double helix:

In a society built on an egalitarian ideal, the notion that all men are not born equal is an anathema to many people. (p. 373)

The prevailing orthodoxy holds that the best way we can help our fellow citizens is by addressing problems with their nurture. [Yet] children will get left behind if we continue to insist that each one has the same potential for learning. (p. 398)

The tabula rasa remains the paradigm of choice among the politically entrenched defenders of some increasingly untenable views of human development. (p. 374)

This tendency to prefer explanations grounded in “nurture” over ones rooted in “nature” has served a useful social purpose in redressing generations of bigotry. Unfortunately, we have now cultivated too much of a good thing. (p. 398)

In a land of equal opportunity, where we are each free to advance as far as our wits will carry us, intelligence is a trait with profound socioeconomic implications. Smart parents not only pass on smart genes; they also tend to rear their children in ways that foster intellectual growth. (p. 379)

Many of the most important genes governing behavior will indeed turn out to be those involved in constructing … the human brain. (p. 393)

Violence … can [also] be viewed through the lens of genetics. Some people are more violent than others. That’s a fact. And violent behavior may be governed by a single gene interacting with environmental factors. (p. 391)

Does DNA knowledge make a genetic caste system inevitable? A world of congenital haves and have-nots? (p. 397)

My view is that, despite the risks, we should give serious consideration to germ-line therapy [where new genes are introduced at conception, and can be passed along to offspring]. I only hope that the many biologists who share my opinion will stand tall in the debates to come and not be intimidated by the inevitable criticism. (p. 401)

Any woman reading these words should realize that one of the most important things she can do as a potential or actual parent is to gather information on the genetic dangers facing her unborn children. (p. 402)

When discussing our genes, we seem ready to commit what philosophers call the “naturalistic fallacy,” assuming that the way nature intended is best. By centrally heating our homes and taking antibiotics when we have an infection, we carefully steer clear of the fallacy in our daily lives, but mentions of genetic improvement have us rushing to run the “nature knows best” flag up the mast. (p. 399)

Science may indeed uncover unpleasant truths, but the critical thing is that they are truths. Any effort, whether wicked or well-meaning, to conceal truth or impede its disclosure is destructive. (p. 372)

Knowledge, even that which may unsettle us, is surely to be preferred to ignorance, however blissful in the short term the latter may be. All too often, however, political anxiousness favors ignorance and its apparent safety. (p. 364)

February 16, 2009 in DNA and Society | Permalink | Comments (0)

Men are Autistic, Women are Schizophrenic

Split Since the time of Descartes, scientists have struggled to carve a niche for themselves where they can work undisturbed by cultural, political, and religious wars.  For example, Descartes devised the so-called mind/brain distinction, whereby scientists agreed to limit their inquiries strictly to the physical world (e.g. the brain and body), and cede dominion of the "mind" and spiritual world to God and the all-powerful Church.

Today, two researchers, Bernard Crespi and Christopher Badcock, are attempting a similar segregation of turf.  Since it’s not politically correct to speak of a genetic basis for human behaviors (nor innate differences among people), they’ve reframed the discussion in terms of mental diseases, which are less threatening to cultural warriors.  Scientists are now free to explore the genetic basis of mental diseases, while they cede discussions of “normal” behavior to the current orthodoxy of cultural enforcers.

So what's their new theory?  According to the New York Times, Crespi and Badcock theorize that:

An evolutionary tug of war between genes from the father’s sperm and the mother’s egg can, in effect, tip brain development in one of two ways. A strong bias toward the father pushes a developing brain along the autistic spectrum, toward a fascination with objects, patterns, mechanical systems, at the expense of social development. A bias toward the mother moves the growing brain along what the researchers call the psychotic spectrum, toward hypersensitivity to mood, their own and others’. This, according to the theory, increases a child’s risk of developing schizophrenia later on, as well as mood problems like bipolar disorder and depression.

In short: autism and schizophrenia represent opposite ends of a spectrum that includes most, if not all, psychiatric and developmental brain disorders. The theory has no use for psychiatry’s many separate categories for disorders, and it would give genetic findings an entirely new dimension.

In other words, there’s a “psychotic spectrum” of genetically influenced human traits (from autism to schizophrenia), with us “normal people” somewhere in the middle.  At the outer reaches of the spectrum are mental diseases,  which scientists are free to study to determine their underlying genetic basis.  Within the broad middle of the spectrum, where genetic variation among humans presumably also leads to different personality traits, the implication will be left to cultural warriors (i.e the "Modern Inquisition") to explore.  (Why do some people have a “fascination with objects” and lack a “sensitivity to the moods of others”?  It must be the way they were raised, they'll say!)  Meanwhile, scientists will slowly work their way to the middle of the spectrum, and finally overcome the PC resistance with definitive proof of the genetic basis of human behavior, perhaps a few years down the road.

November 13, 2008 in DNA and Society | Permalink | Comments (0)

Economics and Genetics

Where do our choices come from?

Dnamoney I’d tell you, but you’d probably disagree.  Most people are not hardwired to understand themselves.  Although we’re really genetic beings reacting to other genetic beings, we don’t see it that way.  We think of ourselves as rational actors, acting in response to other rational actors.

Most people think we have freedom of choice, to do anything we want.  The problem is, we don’t (and can’t) chose our “wants” themselves.  They are part of who we are, as genetic beings.  Our genes are not something we have.  They are something we are.  And the mere 1% genetic difference among humans accounts for our dramatically different choices.

Many people are lucky to be born with innate motivations that coincide with their parents' (and society’s) wishes.  So they often attribute their success to parents and mentors.  Yet it's easy to find counterexamples.  Whenever you hear someone say "my parents made me who I am", you can respond with equal validity that their parents also gave them their genes, and genes come in many different flavors.

As with quantum physics, it seems impossible to step outside the system to observe ourselves objectively.  In quantum physics, the observed and the observer are one.  The process of observation causes the observed to exist.  There are no privileged perspectives. We humans can’t seem to step outside of ourselves either, in our interactions with each other.

We react to each other, without trying to understand those who differ from us.  It's been shown, for example, that political preferences are probably innate. (Soon, there could be a simple genetic test to determine who prefers Fox News over CBS!)  As an extreme example, we don’t identify with serial killers or psychopaths either, even as their motivations are innate.  We simply want to punish and incarcerate them, and forget about them, not understand them. Although we all share 99% of the same DNA, it's also true that two keys may be 99% identical, yet start different cars.

What does it mean to say motivations are genetic?  It’s shorthand for saying “genes create our body infrastructure, including the brain’s circuitry, and design the development process to be self-tuning (via expected experience from our evolutionary history)”.  Genes, which evolved over billions of years, in close association with the environment, are really encapsulated experience from that ancient time, brought forth to the present. Genes now develop our brain circuitry to recognize expected situations in the environment, and to react to them in standard ways.  And genetic diversity means that no two people are motivated by the same things.  Some people prefer rock climbing, and others prefer studying history.

At some level, we are "designed" by our genes to respond to certain environments.  As an analogy, think of a simple example of a human-designed entity.  An elevator is designed to respond to very specific environments (i.e. button presses).  When the 3rd floor button is pressed, it “chooses” to travel to the 3rd floor, of its own free will.  That is who it is.  It’s part of the elevator’s design.  The possible environments (for which it can react) are constrained by the elevator’s design.  Yet it feels unconstrained, and free to act.  Its response seems rational, only because the design had a specific purpose.

Genes are like formulas in a spreadsheet.  Genes are algorithmic.  Yet we don’t all have the same formulas, so the behavioral outcomes differ.  But those outcomes are constrained by the formulas.  We don’t have “free will” to change them, nor do we want to, because they are who we are.

Spreadsheet Humans are not elevators or spreadsheets, of course.  We have hundreds (or perhaps thousands) of innate formulas in our brains, designed by our genes.  The formulas themselves invoke Bayesian and nonlinear algorithms and fuzzy logic, and so are nearly impossible to simulate.  We humans seem unpredictable, only because we have no prediction machine.

The main point is that no two people have the same “formulas” in their brains, due to genetic diversity.  Some people are motivated to seek power, and others are motivated by following power.  Some people take more risk, and are more resilient.  Some people enjoy killing.  Some people are selfless and brave in the face of danger.

How would you teach someone to be motivated by power?  You can’t do it.  You can motivate someone (using their existing motivations), but you can’t give them new ones (since the development of the brain begins within a short time of conception, in utero).  Yet a CEO makes millions of dollars because he has rare genes.  Leadership is innate.  That doesn't make it fair.

Finally, is genetics too complex to understand and predict?  No, because genes reduce complex situations to simple signals.  For example, a powerful general who commands an army of well-trained troops needs only issue a single command (“Attack!”), to begin a war.  You could try to understand the war in terms of the political history, the social context, the history of weaponry, and the personal histories of all involved.  Or you could understand the war in terms of a single signal.

In the same way, humans may have a single “master” gene for certain high-level traits, that can trigger a cascade of activity in thousands of other genes.  (Heck, even a simple drug can turn you into a compulsive gambler!)  My guess is that we’ll find single “master genes” for many human traits and motivations.  (Scientists have already discovered social behavior genes.) In the future, your DNA can be tested for these gene variants, to determine if you have rare leadership qualities, or what consumer preferences you may have.

If motivation is genetic, then our theories of rational agents, free choice, and homogeniety in society are sorely outdated.

October 01, 2008 in DNA and Society | Permalink | Comments (0)

Spit Party at New York fashion show

At their recent spit party in Manhattan, "personalized genetics" company 23andMe wowed the stars, and invited them to have their DNA tested. Just spit in a cup, and have your sample analyzed for $399, a pretty good deal.

Better act fast though.  The FDA is currently cracking down on companies like 23andMe, in an apparent attempt to limit a citizen's right to self-knowledge.  Fortunately, some people are now fighting back against the regulators (see, for example, Wired Magazine's "Top 10 Reasons that Regulators should not hinder Genetic testing")

September 14, 2008 in DNA and Society | Permalink | Comments (0)

Genetic censorship at the FDA

Your genes are something you are, not something you have.  You receive 20,500 genes from your parents, most of which come in a different variety or flavor from your neighbor's genes.  True, some gene variants lead to a disposition for a disease, like cancer or Alzheimer’s.  But it’s not easy to order a diagnostic test to know your gene variants.

Oversight Now the FDA wants to make it even harder.  They want to regulate all genetic tests, and require that any claims on gene function are backed up by peer reviewed journal articles and rigorous clinical studies.

The problem is, most gene variants have nothing to do with disease.  They are responsible for human diversity.  The FDA wants to limit access to all genetic tests, not just those with a relationship to a disease.  If you want to test your gene variants, the FDA wants you prove the function of those genes first.  They want to tie the testing of genetic variants (an objective fact about you) with the claim about the gene's function (e.g. it causes XYZ).

Since there are thousands of gene variants in the body (and the FDA can't possibly review all claims on their function), the FDA is effectively outlawing self-knowledge!  Unless you have millions of dollars to run a clinical study, the FDA won't let you take a genetic test to learn an objective fact about yourself.

It’s a clever trick.   The FDA – a government agency – wants to limit your access to… YOU.  Why?  What's wrong with using the eBay approach instead?  Allow anyone to make claims about the function of a gene variant, and allow "consumers" to rate the credibility and reliability of the source on a public website?  Why must the government attempt to censor our genetic knowledge?

August 03, 2008 in DNA and Society | Permalink | Comments (1)

California bans self-knowledge

Sfbridge In an astonishing move, the state of California has denied individuals' access to their own genetic information.  Under the ruse of protecting consumers, the California government claims that "[genetic] tests have not been validated [by the government] for accuracy or for clinical utility".

Such big brother tactics are an attempt to exclude individuals from understanding our own genetic differences.  If everyone is morally equal, the counter-culture state seems to be saying, why do you need to know your genetic differences?  It's too divisive.  Just let the government worry about it.

Of course, we each have 20,000 genes, and each gene comes in a variety of flavors that make us unique.  How is the government planning to regulate claims on every gene variant?  Why not democratize the process, and allow anyone to come forward with ideas, instead of crudely attempting to suppress it?

June 22, 2008 in DNA and Society | Permalink | Comments (0)

Who's your Daddy? (courtesy of Rite Aid)

Paternity Rite Aid pharmacy now sells an over-the-counter DNA paternity test.  Using a swab, you collect saliva of the mother, the child, and the alleged father.  In 3-5 days, you'll know who's really your daddy.

April 24, 2008 in DNA and Society | Permalink | Comments (0)

What is Eugenics?

Eugenics is the theory that humans can influence our own evolution, through selective breeding, or genetic enhancement.  Usually, the word "eugenics" has a highly negative connotation (for good reason), implying government sponsorship of breeding programs and forced sterilization of "undesirables".

For example, between 1934 and 1975, Sweden sterilized more than 62,000 mentally ill people.  The Nazis in Germany were much worse, of course, simply killing those they considered innately "inferior".  Government involvement in human breeding or genetic selection is always evil, and any sort of genetic discrimination is also morally wrong.

On the other hand, most people agree that elimination of genetic diseases by personal choice is a good idea.  For example, Ashkenazi Jews have effectively used screening tests to virtually eliminate Tay-Sachs disease.  I wouldn't call this "eugenics" (since it's not government-sponsored) but it's certainly an example of human-directed evolution, since it altered the prevalence of certain genes in the population.

Keep in mind that there are two types of human life: potential and living.  If an egg and sperm are not yet joined (i.e. conception has not occurred), it's fair game to discuss the "potential life" that might result from their joining.  The only time it's morally acceptable to talk about "good genes" and "bad genes" is prior to conception.  Yet, sometime after conception, when the fetus reaches viability, it achieves moral equality with all other human life.  No one currently living should ever be genetically discriminated against for any reason.

Joneses_2 So how far should personal choice over genetic selection (of one's potential children) be allowed to go?

Aside from eliminating genetic diseases, should we allow personal choice over other genetic traits?  A 1993 March of Dimes poll found that 11% of parents said they would abort a fetus whose genome was predisposed to obesity. Four out of five would abort a fetus if it would grow up with a disability. Forty-three percent said they would use genetic engineering if available simply to enhance their child's appearance.

I think abortion should be discouraged (and eventually outlawed) in modern society.  Yet would this sort of genetic enhancement (to create "designer babies") be considered eugenics?  In my opinion, no, as long as the decisions are made by parents, not governments, and the choice is made prior to viability of the fetus.  Better yet to intervene prior to conception, since the window of time between conception and viability is a morally gray area.  (Roe v. Wade defines it as 7 months, which is far too late... see also what the Vatican has to say).

Would there be "cultural pressure" to genetically enhance your children, if everyone around you was doing so?  Probably (that's why genetic counseling services will be a growing industry).  If scientists identified a gene enhancement technique that could make your children more intelligent, and all your neighbors were using it, would you have the courage to buck the trend?  Should you?

In any case, choosing to conform (or not) to cultural expectations is different from government coerced eugenics.

April 13, 2008 in DNA and Society | Permalink | Comments (4)

Big Brother wants to be the "gatekeeper" of your genetic information

Two government agencies, the Food & Drug Administration (FDA) and Federal Trade Commission (FTC), are being advised to act as "gatekeepers", to limit citizen's knowledge of our own DNA.

Big_brother_2 Specifically, the Genetics and Public Policy Center at Johns Hopkins University is recommending that the FDA regulate claims made by genetic testing services (especially direct-to-consumer tests), and provide more stringent oversight of the 1,500 currently available genetic tests, and for the FTC to  “take decisive action against companies making false or misleading claims about the benefits of genetic testing".

Sounds reasonable, right? Wrong.

First, taking a genetic test can't hurt you physically.  If someone sells a flawed genetic test, the word will get out pretty quickly, and that vendor will lose credibility.  It's self-policing. But nobody will be hurt.

Second, the results of a genetic test are objective facts. If a test shows you have variant A (or B or C) of a gene, it's simply a fact about you.  The vendors of genetic tests are simply providing you with objective facts about yourself.  If insurance companies won't pay for a genetic test, that's their decision, but direct-to-consumer tests should not be regulated, except for basic quality.

Marketplace Third, many scientists and others will offer interpretations or claims about the results of your genetic tests, in a vast marketplace of ideas.  The science (and therefore the accuracy of the claims) will improve every year. Some people making these claims will have more credibility than others. But there are ways to handle this, without government involvement.  We each have 20,500 genes, all coming in different variants or flavors. The government can't possibly keep track of all the claims made on each gene variant, much less attest to their veracity.

What does it mean if I possess variant A of gene XYZ?  Scientists (and bloggers) around the world will have opinions on the function of each gene variant.  That's a democratic messy process, and ultimately it leaves the consumer.to weigh the credibility of the source. Some (perhaps most) claims will ultimately be proven incorrect, especially claims by those scientists who are under constant pressure to be politically correct instead of scientifically correct.

Still, the government should keep its distance, as it did with the birth of the Internet, and the regulation of herbal medicines.  Extreme government involvement in genetics is, ultimately, eugenics.  The future of genetic understanding will come through collaboration, community, contention, and debate, not government control.

April 03, 2008 in DNA and Society | Permalink | Comments (1)

Secretly testing DNA from stray hairs and cigarette butts

Anyone who watches modern TV crime drama knows that obtaining DNA samples (hair, sweat, blood, or saliva) from an alleged perpetrator is often done secretly, without a warrant or consent of the suspect.

According to a story in the New York Times:

The practice, known among law enforcement officials as “surreptitious sampling,” is growing in popularity even as defense lawyers and civil liberties advocates argue that it violates a constitutional right to privacy.

Hairpulling Law enforcement argues that lost hairs and saliva are "traces of DNA [that suspects] unwittingly shed" and should not require a warrant before testing.

But they should.  Everyone's DNA tells a rich personal story, and our knowledge grows richer every day.  It should be illegal to test a known subject's DNA, without a warrant.

April 03, 2008 in DNA and Society | Permalink | Comments (0)

Recent Posts

  • Employers not compliant with new GINA law
  • Motivation, Dopamine, and Schopenhauer
  • Nicholas Wade's Before the Dawn
  • Sandel's Genetics and Morality
  • Genetic testing in China
  • Performance vs. Potential
  • European Invasion
  • What is Transhumanism?
  • Gregory Stock's DNA
  • Saletan's Race Debate

Recommended Reading

  • Allen Buchanan: From Chance to Choice: Genetics and Justice

    Allen Buchanan: From Chance to Choice: Genetics and Justice

  • Jonathan Glover: Choosing Children: Genes, Disability, and Design (Uehiro Series in Practical Ethics)

    Jonathan Glover: Choosing Children: Genes, Disability, and Design (Uehiro Series in Practical Ethics)

  • Gregory Stock: Redesigning Humans: Choosing our genes, changing our future

    Gregory Stock: Redesigning Humans: Choosing our genes, changing our future

  • John Harris: Enhancing Evolution: The Ethical Case for Making Better People

    John Harris: Enhancing Evolution: The Ethical Case for Making Better People

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