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    by Will Frehley. If leadership is genetic, what sort of DNA should a charismatic robot have?

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Drugs I'd like to see

The difference in motivational levels among people is innate.  Clearly, you spend more time doing what interests (motivates) you, and your interests differ from other people around you.  What you spend time doing (“time on task”) leads to greater ability (intelligence, analytical ability, leadership skills).  Greater ability leads to greater social rewards.  Therefore, social rewards (big paychecks, etc) are linked to our gene variants.

Mattdavies Because not everyone is motivated by things that lead to "success" in the modern information age, we see a fundamental genetic inequality in society.  However, even if it were possible to create drugs to remedy the problem, the FDA would never approve them, since its mandate is to focus on diseases, not human enhancement. Still, how many people take Viagra for a disease/condition (erectile dysfunction), and how many take it for enhancement?

So here is a list of drugs I’d love to see that would address some of the social inequity caused by innate differences among people, along with the "formal" disease or indication:

  • Enhanced memory drugs – treats “mild cognitive impairment”
  • Enhanced charisma drugs – treats “social anxiety disorder” or "diminished social affect"
  • Enhanced intelligence drugs – also treats “mild cognitive impairment”
  • Enhanced drive – treats “low self-esteem disorder” and “low affect”
  • Anti-criminal-behavior drugs – treats “low anger threshold disorder”
  • Anti-sociopathic drugs – treats “low social empathy disorder”
  • Enhanced leadership ability drugs - treats “social anxiety disorder” and “low self-esteem disorder” and “low social empathy disorder”
  • Enhanced spirituality drugs - treats "low affect" and depression

Reductionism

A recent article in the journal Science announced a stunning and exciting new finding:

individuals with one or two copies of the short allele of the serotonin transporter (5-HTT) promoter polymorphism, which has been associated with reduced 5-HTT expression and function and increased fear and anxiety-related behaviors, exhibit greater amygdala neuronal activity

Amygdala2 OK, maybe it's not all that exciting at first glance!  Science is full of reductionist jargon, and scientists don't appreciate it when you try to draw abstract conclusions based on the narrow experimental evidence.  In any case, here's my interpretation of the article:

Everyone has the same 20,000 genes.  One of those genes is called SLC6A4 (previously called 5-HTT).  However, different people have different versions of that gene, the long variant and the short variant.  [If you really want to know the technical details, the long variant has 16 repeats of a 44 letter DNA sequence, and the short version has 14 deletions of that repeated sequence, called a "copy number variation" (CNV)]

Paver2 Technically, the genetic difference lies in the so-called promoter region (or "on switch") just in front of the gene, not in the gene itself.  But in any case, it's all DNA.  Specialized proteins (called "transcription factors") latch onto this promoter region, looking very much like highway paving machines.  The promoter region (short or long variety) acts as the construction supervisor, telling the machine how much protein to make based on the gene template (or how much pavement to lay down).

Promoter2_1 It turns out that people with the short version of the gene have a more active amygdala, a structure in the brain (see the red area in the top picture) involved in processing negative emotions, and thus they have a greater response to fearful stimuli than people with the longer variant of the gene.  Your genes at work!

Correlation is not the same as causation, of course.  For example, people with the HLA-A1 gene variant tend to use chopsticks, but that doesn't mean HLA-A1 causes the use of chopsticks.  It's simply a more common gene variant in Asians than Caucasians, and Asians tend to use chopsticks.  If you wanted to prove that HLA-A1 was the "chopstick gene", you would have to show (among other things) the contrapositive, that Asians who don't use chopsticks also don't have the HLA-A1 gene variant.

Success of Asian students: culture or genes?

Asian Some commentators are bemoaning the fact that 46% of students at the University of California, Berkeley, are now Asian.  But I think it's great.  It proves that Americans are so certain in our principles, that we allow meritocracy to flourish, whatever the outcome.  If Asians have the highest scores, of course they should be the ones who are accepted.  If this leads to racial imbalances at the university level, so be it.

Are Asians innately smarter that other people?  I'm not so sure.  (Perhaps the new Asian Genome Study will tell us!)  In any case, I think the Western educational style of "thinking for yourself" puts a burden on many people, and slows us down at first, especially in our ability to identify patterns. 

Some Chinese students I know appreciated the fact that in China they were told what classes to take, and what to study, so they didn't need to worry or question anything.  They just studied what was put in front of them.  The Asian style is often one of rote memorization, accepting what you are told (whether it makes sense or not), and doing deeper analysis later.

Still, I believe there will be some short-term issues with the influx of Asians at American universities.  According to Stanford professor Hazel R. Markus (in a recent NYT article):

[S]tudies have found that Asian students do approach academics differently. Whether educated in the United States or abroad, she says, they see professors as authority figures to be listened to, not challenged in the back-and-forth Socratic tradition. “You hear some teachers say that the Asian kids get great grades but just sit there and don’t participate,” she says. “Talking and thinking are not the same thing. Being a student to some Asians means that it’s not your place to question, and that flapping your gums all day is not the best thing.”

One study ... looked at Asian-American students in lab courses, and found they did better solving problems alone and without conversations with other students. “This can make for some big problems,” [says Markus], like misunderstandings between classmates. “But people are afraid to talk about these differences."

For these reasons, I don't believe Daniel Golden when he says Asians have become the “new Jews" (in other words, the new academic superstars).  Jews have a culture and tradition of debate, law, and analysis.  Asians don't. 

This is rather alarming, because the American model is based on abstract principles and openness (which many Asians I know think are hopelessly naive):

  • A free (and adversarial) press to investigate corruption
  • Democracy (to replace corrupt leaders in a timely manner)
  • Individual rights and moral equality
  • Rule of law, not rule of man
  • Openness and transparency in government and business
  • Creativity based on individual opinion
  • Dynamic capitalism, where wealth is created by new ideas and "creative destruction", not copies of old ideas

Still, as with any immigrant community, we always see difficulties at first.  Once immigrants become more assimilated, they nearly always transform the culture, and leave it better than it was before.  So, I say, welcome to the Asian invasion, and please bring your genes!

Anyway, back to genetics.  In my opinion, every selection activity (whether of students, or of leaders in a corporation) is always a form of genetic selection.  You can't have talent without genes, because talent emanates from motivation and desire, which is always innate.  And a recent scientific publication reports that 25% of genes studied differ in their level of activity between Europeans and Asians.

Babydoll Are Asian students innately different from Western students, or are they molded by their Confucian culture, which teaches deference toward elders, consensus-building, and rote learning?  In my experience, even American Born Chinese (ABCs) have a greater respect for authority than non-Asians, and a more calm disposition, with a greater willingness to defer gratification and work hard.  Confucianism may reflect the genetic character of the people, instead of vice versa.  Still, native-born and American-born Chinese don't tend to hang out together, since the native-born Chinese find ABCs "too American" and noisy.

I think it's worthwhile looking at the representive aspects of Asian culture, and try to determine whether these could be genetic.  According the NYT article:

  • “In Asian families, the No. 1 job of a child is to be a student. Being educated — that’s the most honorable thing you can do”
  • “The bottom line message from the family is the same: work hard, defer gratification, share sacrifice and focus on the big goal.”
  • Students are happy at Berkeley because “you really feel like you don’t stand out”

So what innate motivations are at work here, that separate Asians and other groups?  Let’s deconstruct this a bit (with the caveat that this is merely speculation for further research):

  • The desire (or motivation) to be "honorable" and respect authority could be innately stronger in Chinese than in other people
  • The ability to "defer gratification" (and spend long hours in lonely labs) could be greater as well
  • Sensitivity to "social shame" is always relative, but Chinese could be innately more reserved on average.  Fear of "standing out" is clearly innate, since you can't teach a fear
  • I know a number of Chinese couples who live apart, working in separate cities.  The need for daily intimacy could be less intense in Chinese
  • Deference to authority is also innate, since how would you teach it?  It has to feel right.  It is amplified by the Confucian culture, but only because it resonates with people’s innate inclinations.
  • It's possible that Chinese have brains that are more adept at memorizing and pattern recognition, but I have no proof of that.  I do remember a story about a guy from Thailand (not Chinese) who was an expert Scrabble player, because he memorized the entire English dictionary!

Eyes2 So my conclusion is:  Asians probably have some different innate temperaments (on average) from other groups in America.  And that's fine.  The culture of Confucianism will still take a few generations to die out (which is a good thing, because it's incompatible with American values).  But that's simply the normal process of assimilation.  Would you rather live in a culture where everyone is supersmart (because there are no fixed rules, and knowing the context is all-important), or less smart (but where the rules are well known to all)?

Genes and donut holes

Donut When studying genes, we must not forget what they really are: embodied experience from the distant past, manifest in the present as physical form.  An axe, as an analogy, is a physical form defined by its history.  Many humans, over thousands of generations, perfected the axe's form.  What we see today is an axe that is well designed to perform a function, stripped of all superflous matter.  What we don't always see is its history or its true purpose.

Genes are like time machines, bringing knowledge from the past into the present.  Like axes, they are elegant works of art.  They are all they need to be, and no more.

Genes are often defined by what can't be seen (think "donut holes").  A gene may be active in very specific situations, sometimes only for a few hours in utero.  Unless you know its complete history (which is impossible), it's difficult to understand its purpose.

Genes can only be affected by the environment only to the degree to which they were designed to be affected by the environment.  The hooks provided by the genes are often quite subtle.  Sometimes you can't see what a gene's purpose really is, unless you already know what to look for, and can devise the conditions for the gene to express itself.

Genes: Blueprints or Recipes?

Recipe Scientists are often asked whether genes act as blueprints, or instead as recipes, for human development.  According to NYU Professor Gary Marcus, genes are not blueprints, because there are simply not enough genes to describe exactly how each of our billions of cells should fit together.  Rather, he says, genes are part of "self-regulating recipes" whereby gene activity is designed to respond to environmental cues in the course of natural development.

Whereas I'm sympathetic to this line of reasoning, I still like the blueprint analogy, because it provides fewer and simpler variables for:

  1. Transmission of discrete traits
  2. Evolutionary selection

Blueprint Human society is filled with specialized actors.  Some are brave, some are smart, some are leaders, some are followers.  The distribution of these traits is unevenly balanced, in order for society to run "smoothly".  (Smoothness and fairness are, of course, two different things).  In order for these traits to be balanced, bravery, intelligence, and leadership ability must be regulated by simple on-off switches in the genome, otherwise it would be too complicated to allocate and distribute these traits in specified proportions across society.

In other words, while there may be thousands of genes involved in specifying the "recipe" for a leader (how s/he reacts, responds, displays emotions, etc), there must be a fairly small number of genes that act as the blueprint or master switch, to enable one recipe over another.  One only need to do an online search for "single gene responsible for" and "scientists shocked/perplexed/amazed" to find genes like Bax that act as master switches.

Also, evolution of species would be more rapid (in the face of changing environments) if selection were made among a small number of variables.  For example, the genes responsible for the development of beaks on Darwin's finches may act as recipes, but behind these must exist master genes for selection pressure to quickly act upon.

Humans differ genetically by 1%

Scientists are now establishing a more accurate database of human genetic variation, after the shocking news late in 2006 that scientists underestimated the amount of genetic difference among humans by a factor of 10!  We humans are now understood to be 99% alike, not 99.9% alike as previously reported.

Gene It turns out that 12% of our genome is involved in copy number variations (CNVs), with 1% of our genome actually different from other people.  CNVs include repeating and deleted sequences of DNA, implying that some people may have more DNA than other people!  These CNVs affect 2,900 genes (360 million genetic bases, or "letters"), including 15% of known disease gene variants.

The CNV variations are in addition to known single base ("letter") differences (SNPs), making a total of 30 million DNA differences among people (1% of the genome).  These include:

  • 1.5 million single-letter differences (SNPs)
  • 24 million letters of unmatched sequences among people (i.e. unique among human subgroups)
  • 3.5 million multi-copy (repeating) sequences
  • 1 million letters in inverted sequence

Free will

Here's a nice summary of current scientific understanding on free will, written by Dennis Overbye in the New York Times:

A bevy of experiments in recent years suggest that the conscious mind is like a monkey riding a tiger of subconscious decisions and actions in progress, frantically making up stories about being in control. [Our] conscious brain [is] only playing catch-up to what the unconscious brain [is] already doing.

In other words, our unconscious (genetically programmed) brain perceives the world for us, motivates us toward some situations over others, colors our experiences with pre-wired dispositions (emotions), and triggers our reactions.  The higher brain is left to make up (confabulate) reasons for why we did what we did, based on the illusion of free will.

Culturewars One concern raised in the article is whether "talking about this in public will fan the culture wars," as if scientific truth should be subjected to a popularity contest.  Scientists are supposed to follow the facts, and do the right thing in the face of opposition, not bury their noses in the sand!  Fortunately, it seems British publications are willing to be less politically correct than Americans.  For example, the Economist magazine recently reported another case against free will:

In the late 1990s a previously blameless American began collecting child pornography and propositioning children. On the day before he was due to be sentenced to prison for his crimes, he had his brain scanned. He had a tumour. When it had been removed, his paedophilic tendencies went away. When it started growing back, they returned. When the regrowth was removed, they vanished again. Who then was the child abuser?

It's easy to see how a brain tumor could remove your capabilities (like ability to speak or walk), but how was it in this case able to add new (albeit evil) complex desires and motivations, unless these already existed in the brain (merely unleased by - not caused by - the tumor)?

The same question arises with gambling.  Certain people -- who previously never felt the urge to gamble -- suddenly became addicted to gambling after taking a certain drug.  Drugs are very simple molecules... there is no "gambling-ness" in the drug itself.  The drug is simply unlocking a complex behavior that we already have inside.